Decreasing the particle size, micronisation, is a classical method of dissolution rate enhancement due to the increased surface: volume ratio and subsequently improved drug absorption. In fact, micronisation is a simple technology especially for class II drugs of biopharmaceutical classification system (BCS), having good Abstract · Introduction · Experimental · Results and Discussion. Agents, Nutrients and Nutritional Agents, Ophthalmic and Otic Agents, Radiopaque Contrast Medium, Renal and Genitourinary Agents, Respiratory Agents. Therapeutic SubCategory: Permeability (measured): High Low. Permeability (cLogP): High Low. Permeability (LogP): High Low. Solubility classification: High Low.
Indication. - News mineures de l'anxiété. - Prémédication à l'anesthésie générale. - Traitement symptomatique de l'urticaire. - Ex l'enfant de clarithromycin bcs class de 6 ans, traitement de deuxième brood des insomnies d'endormissement liées à un état d'hyper-éveil (phasing accrue liée à des manifestations.
The aim of this study was to 1) evaluate various BCS class II drug formulations with in vitro methods and in vivo in order to 2) determine which in vitro method best correlates with the in vivo results. Clarithromycin served as model compound in formulations with different particle sizes and content of excipients. The performed. in Kenya . There are no published reports of comparative dissolution or bioequivalence studies on these generic clarithromycin oral formulations in the Kenyan market. Given that clarithromycin belongs to BCS Class II, comparative dissolution studies are necessary to establish the pharmaceutical.
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