Dosage should be individualized for maximum beneficial effect. While the usual daily dosages given below will meet the needs of most patients, there will be some who require doses greater than 4 mg/day. In such cases, dosage should be increased cautiously to avoid adverse effects. Usual Adult Dose for Anxiety. Immediate-release tablets/disintegrating tablets: to mg orally administered 3 times a day. Maximum dose: 4 mg orally administered in divided doses. Comments: The lowest possible effective dose should be administered and the need for continued treatment reassessed frequently.
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times the maximum recommended daily human dose of 10 mg/day. Alprazolam also was not mutagenic in vitro in the DNA Damage/Alkaline Elution Assay or the Ames Assay. Alprazolam produced no impairment of fertility in rats at doses up to 5 mg/kg/day, which is. 25 times the maximum recommended daily human. Alprazolam was not mutagenic in the rat micronucleus test at doses up to mg/kg, which is times the maximum recommended daily human dose of 10 mg/day. Alprazolam also was not mutagenic in vitro in the DNA Damage/Alkaline Elution Assay or the Ames Assay. Alprazolam produced no impairment of fertility in.
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